Faraz Chogan
Liposomes and nanofibers are widely used as nanocarriers for controlled drug delivery systems due to their favorable features. These nanostructures’ ability to encapsulate large amounts of drugs, minimizing unwanted side effects, high efficacy, biodegradable nature, and low toxicity has attracted the interest of researchers. In this work, Metformin-HCl were incorporated into the liposome nanoparticles, and the following were loaded into the PCL-Chitosan / PVA core-shell electrospun nanofibers for controlled release of metformin-HCl over the required time for the wound healing process. The nanocarrier’s physicochemical and mechanical properties, including degradation rate, water uptake, drug loading efficiency, in vitro release profile, and mechanical characteristics, have been investigated.