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Neutrophil Gelatinase-Associated Lipocalin and Matrix Metall | 46212

神経学および神経生理学ジャーナル

ISSN - 2155-9562

概要

Neutrophil Gelatinase-Associated Lipocalin and Matrix Metalloproteinase-9 as Potential Biomarkers for Stroke: A Pilot Study

Yi-Chinn Weng and Wen-Hai Chou

Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL) is acutely induced after
ischemic stroke. Matrix metalloproteinase-9 (MMP-9) has been associated with hemorrhagic transformation possibly
by promoting the degradation of extracellular matrix of cerebral blood vessels. NGAL forms heterodimer with MMP-9
and stabilizes the enzymatic activities of MMP-9 by protecting it from degradation. In the present study, we
determined the concentrations of NGAL, MMP-9 and the heterodimeric complex in the sera of patients with ischemic
and hemorrhagic stroke as well as healthy subjects by Western blotting, affinity purification, and ELISA. Our results
show that the serum levels of NGAL, MMP-9, and NGAL-MMP-9 complex in hemorrhagic stroke patients were
significantly higher than the ischemic stroke and control subjects. The data suggest a potential usage of NGAL,
MMP-9 and the heterodimeric complex as biomarkers to detect hemorrhagic stroke and distinguish it from ischemic
stroke