p53 mutations' prognostic significance in metastatic colorec | 100552


ISSN - 2732-2654


p53 mutations' prognostic significance in metastatic colorectal cancer: a comprehensive study and meta-analysis

Lisa Watson

One of the genes that is most frequently altered in colorectal cancer (CRC) is P53. The goal of the current investigation was to establish a reliable estimate of the prognostic significance of p53 mutations in individuals with metastatic CRC. The Preferred Reporting Item for Systematic Reviews and Meta-Analysis 2020 standards were followed for conducting this meta-analysis. PubMed and Google Scholar were used to look up studies written in English and published in the previous 10 years. the presence of Hazard Ratios (HRs) with 95% Confidence Intervals (CIs), and 1) relationship with overall survival as the final selection criteria. Using the Newcastle-Ottawa Scale and the QUIPS instrument, the articles were assessed for quality and bias risk. The Hartung-Knapp-Sidik-Jonkman method was used to do the meta-analysis, and the findings were presented in traditional Forest plots. Statistics like I2 and Tau2 were used to gauge study heterogeneity. The p53 mutation's connection to clinicpathological factors was investigated using the 2 test